Mitochondrial Dysfunction in Idiopathic Parkinson Disease
نویسندگان
چکیده
منابع مشابه
Mitochondrial dysfunction in Parkinson disease: evidence in mutant PARK2 fibroblasts
Mutations in PARK2, encoding Parkin, cause an autosomal recessive form of juvenile Parkinson Disease (JPD). The aim of the present study was to investigate the impact of PARK2 mutations on mitochondrial function and morphology in human skin fibroblasts. We analyzed cells obtained from four patients clinically characterized by JPD, harboring recessive mutations in PARK2. By quantitative PCR we f...
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1.1 Clinical characteristics of Parkinson’s disease Parkinson’s disease (PD) is an old-age neurodegenerative disease with a small but significant genetic risk. The prevalence of PD is of 0.3% in the whole population, affecting more than 1% of the humans over 60 years of age (de Lau & Breteler, 2006). Parkinson ́s disease is characterized by the progressive loss of dopamine due to degeneration of...
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Dysfunction of mitochondria is frequently proposed to be involved in neurodegenerative disease. Deficiencies in energy supply, free radical generation, Ca(2+) buffering or control of apoptosis, could all theoretically contribute to progressive decline of the central nervous system. Parkinson disease illustrates how mutations in very different genes finally impinge directly or indirectly on mito...
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Although a subject of intense research, the etiology of Parkinson disease (PD) remains poorly understood. However, a wide range of studies conducted over the past few decades have collectively implicated aberrant mitochondrial homeostasis as a key contributor to the development of PD. Particularly strong support for this came from the recent demonstration that parkin, a familial PD-linked gene,...
متن کاملMitochondrial Dysfunction in Parkinson's Disease
Parkinson’s disease (PD) is the most common neurodegenerative movement disorder characterized by numerous motor symptoms, including bradykinesia, hypokinesia, rigidity, resting tremor, and postural instability and non-motor symptoms, such as autonomic dysfunction, sleep abnormalities, depression, and dementia [1-3]. The motor clinical manifestations are the preferential loss of dopaminergic (DA...
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ژورنال
عنوان ژورنال: The American Journal of Human Genetics
سال: 1998
ISSN: 0002-9297
DOI: 10.1086/301812